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Semaglutide / Tirzepatide

GLP-1 Metabolic Research

Weekly-dosed protocols for GLP-1 and GIP receptor studies. Reconstitution math and dose escalation follow SURMOUNT / SURPASS / STEP trial designs.

Research goal

GLP-1 axis and metabolic investigations

Duration

12–52 weeks depending on study endpoints

Weekly schedule

Week 1–40.25 mg once weekly (starting dose)
Week 5–80.5 mg once weekly
Week 9–121.0 mg once weekly
Week 13+Escalate per protocol (max 2.4 mg semaglutide / 15 mg tirzepatide)

Reconstitution notes

  • Reconstitute 5mg vial with 2 mL bacteriostatic water → 0.1 mL = 0.25 mg
  • Start low, escalate every 4 weeks
  • Rotate injection sites in the research protocol

Peptides in this protocol

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For Research Use Only. This protocol summarizes doses reported in peer-reviewed studies. It is not medical advice.